STIG: Generation and simulated sequencing of synthetic T cell receptor repertoires

Abstract excerpt

T cell receptor repertoire inference from DNA and RNA sequencing experiments is frequently performed to characterize host immune responses to disease states. Existing tools for repertoire inference have been compared across publicly available biological datasets or unpublished simulated sequencing data. Evaluation and comparison of these tools is challenging without common data sets created from a known repertoire...

Topics

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• Algorithms
• Antibody Diversity
• Cancer Immunotherapy and Biomarkers
• CAR-T cell therapy research
• High-Throughput Nucleotide Sequencing
• Immune Cell Function and Interaction
• Immunoglobulin Variable Region
• Receptors, Antigen, T-Cell

Identifiers and source

Literature Corpus work

32d00b0a-aca5-5ee7-aae8-1128b1f116e8

DOI

10.1101/2020.02.28.969469