Article

Detecting T cell receptor rearrangements <i>in silico</i> from non-targeted DNA-sequencing (WGS/WES)

2017-10-13

Abstract excerpt

To better understand the composition of heterogeneous tissue samples used in generating large genomic datasets, we developed a method for estimating the abundance of T cells within the cellular population. Somatic recombination of chromosomal DNA in T cells creates a vast repertoire of structurally divergent T cell receptors (TCRs) that recognize an array of non-self proteins. It also generates a genomic signature...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fdea337f-78b7-5923-94a6-94291d85a155
DOI: 10.1101/201947

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Detecting T cell receptor rearrangements <i>in silico</i> from non-targeted DNA-sequencing (WGS/WES)DOI 10.1101/201947Read

High-throughput sequencing of the T-cell receptor repertoire: pitfalls and opportunities.Semantic proximity Read

Profiling tissue-resident T cell repertoires by RNA sequencingSemantic proximity Read

Rigorous benchmarking of T cell receptor repertoire profiling methods for cancer RNA sequencingSemantic proximity Read

Single Cell T Cell Receptor Sequencing: Techniques and Future ChallengesSemantic proximity Read

Rigorous benchmarking of T-cell receptor repertoire profiling methods for cancer RNA sequencingSemantic proximity Read

The human T‐cell receptor repertoire in health and disease and potential for omics integrationSemantic proximity Read

Profiling Germline Adaptive Immune Receptor Repertoire with gAIRR SuiteSemantic proximity Read

STIG: Generation and simulated sequencing of synthetic T cell receptor repertoiresSemantic proximity Read

Ultrasensitive allele inference from immune repertoire sequencing data with MiXCR.Semantic proximity Read

T Cell Receptor Beta Germline Variability is Revealed by Inference From Repertoire DataSemantic proximity Read

T-Cell Receptor Repertoire Sequencing and Its Applications: Focus on Infectious Diseases and CancerSemantic proximity Read

Practical guidelines for B-cell receptor repertoire sequencing analysisSemantic proximity Read