Characterization of Ws mutant allele of rats: a 12-base deletion in tyrosine kinase domain of c-kit gene.

Article

Characterization of Ws mutant allele of rats: a 12-base deletion in tyrosine kinase domain of c-kit gene.

Blood - 15 Oct 1991

Tsujimura T, Hirota S, Nomura S, Niwa Y, Yamazaki M, Tono T, Morii E, Kim H M, Kondo K, Nishimune Y

Abstract excerpt

Homozygous mutant rats at the newly found white spotting (Ws) locus were anemic and deficient in mast cells and melanocytes. Because the phenotype of Ws/Ws rats resembled the phenotype of mice possessing a double-gene dose of mutant alleles at the W locus and because the c-kit gene was mapped at...

Topics

Alleles
Animals
Base Sequence
Chromosome Deletion
Molecular Sequence Data
Protein-Tyrosine Kinases
Rats
Rats, Inbred BN
Rats, Mutant Strains

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