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Article

Age-dependent amelioration of hypoplastic anemia in Ws/Ws rats with a small deletion at the kinase domain of c-kit.

Blood - 1 Dec 1993

Morimoto M, Kasugai T, Tei H, Jippo-Kanemoto T, Kanakura Y, Kitamura Y

Abstract excerpt

The white-spotting (Ws) locus of rats represents a 12-base deletion of the c-kit receptor tyrosine kinase. Homozygous Ws/Ws rats are deficient in melanocytes, mast cells, and erythrocytes. Although mice possessing two mutant alleles at the c-kit (W) locus, such as mice of W/Wv genotype, show severe anemia even in adult age, the anemia of Ws/Ws rats remarkably ameliorated with age. We investigated the mechanism of...

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PMID: 7694680

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EPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Age-dependent amelioration of hypoplastic anemia in Ws/Ws rats with a small deletion at the kinase domain of c-kit.PMID 7694680Read ↗

Anemia and mast cell depletion in mutant rats that are homozygous at "white spotting (Ws)" locus.Semantic proximity Read ↗

Characterization of Ws mutant allele of rats: a 12-base deletion in tyrosine kinase domain of c-kit gene.Semantic proximity Read ↗

Rescue of lethal c-KitW/W mice by erythropoietin.Semantic proximity Read ↗

Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.Semantic proximity Read ↗

Characterization of cultured mast cells derived from Ws/Ws mast cell-deficient rats with a small deletion at tyrosine kinase domain of c-kit.Semantic proximity Read ↗

W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor.Semantic proximity Read ↗

The murine W/c-kit and Steel loci and the control of hematopoiesis.Semantic proximity Read ↗

C-kit gene is expressed by skin mast cells in embryos but not in puppies of Wsh/Wsh mice: age-dependent abolishment of c-kit gene expression.Semantic proximity Read ↗

White-spotting mutations affect the regenerative differentiation of testicular germ cells: demonstration by experimental cryptorchidism and its surgical reversal.Semantic proximity Read ↗

Combined action of c-kit and erythropoietin on erythroid progenitor cells.Semantic proximity Read ↗

Phenotypic reversions at the W/Kit locus mediated by mitotic recombination in mice.Semantic proximity Read ↗

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