Article
Age-dependent amelioration of hypoplastic anemia in Ws/Ws rats with a small deletion at the kinase domain of c-kit.
Blood - 1 Dec 1993
Morimoto M, Kasugai T, Tei H, Jippo-Kanemoto T, Kanakura Y, Kitamura Y
Abstract excerpt
The white-spotting (Ws) locus of rats represents a 12-base deletion of the c-kit receptor tyrosine kinase. Homozygous Ws/Ws rats are deficient in melanocytes, mast cells, and erythrocytes. Although mice possessing two mutant alleles at the c-kit (W) locus, such as mice of W/Wv genotype, show seve...
Topics
- Age Factors
- Anemia, Aplastic
- Animals
- Erythropoietin
- Gene Deletion
- Genotype
- Hematocrit
- Mice
- Mice, Inbred C57BL
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-kit
- Rats
- Rats, Mutant Strains
- Receptor Protein-Tyrosine Kinases
- Receptors, Colony-Stimulating Factor
- Recombinant Proteins