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Article

Characterization of cultured mast cells derived from Ws/Ws mast cell-deficient rats with a small deletion at tyrosine kinase domain of c-kit.

Blood - 15 Feb 1994

Tei H, Kasugai T, Tsujimura T, Adachi S, Furitsu T, Tohya K, Kimura M, Zsebo K M, Newlands G F, Miller H R

Abstract excerpt

The Ws mutant allele of rats represents a 12-base deletion at the tyrosine kinase domain of the c-kit gene. Although homozygous Ws/Ws rats were deficient in both connective tissue-type mast cells (CTMC) and mucosal-type mast cells (MMC), mast cells did develop when bone marrow cells of Ws/Ws rats were cultured in the presence of concanavalin A-stimulated spleen cell conditioned medium (ConA-SCM). Although the...

Topics

Animals
Antibodies, Monoclonal
Bone Marrow Cells
Cell Adhesion Molecules
Cell Division
Cells, Cultured
Concanavalin A
Culture Media, Conditioned
Endopeptidases
Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fluorescent Antibody Technique

Hematopoietic Cell Growth Factors

Kinetics

Lymphocyte Activation

Lymphocytes

Mast Cells

Nerve Growth Factors

Phenotype

Source

Identifiers

PMID: 7509212

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7509212-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Characterization of cultured mast cells derived from Ws/Ws mast cell-deficient rats with a small deletion at tyrosine kinase domain of c-kit.PMID 7509212Read ↗

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