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Article

recessive spotting: a linked locus that interacts with W/Kit but is not allelic.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Apr 1998

Bennett D C, Trayner I D, Piao X, Easty D J, Klüppel M, Alexander W S, Wagner E F, Bernstein A

Abstract excerpt

BACKGROUND: The murine coat-colour mutation recessive spotting (rs) maps very closely to the W/Kit locus, encoding the proto-oncoprotein Kit, the protein tyrosine kinase receptor for stem cell factor. Kit is important in the development of melanocytes, germ cells, interstitial cells of Cajal (ICC) and haemopoietic lineages, including mast cells. rs has never been genetically separated from Kit, and interacts with...

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Identifiers

PMID: 9663658
DOI: 10.1046/j.1365-2443.1998.00184.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

recessive spotting: a linked locus that interacts with W/Kit but is not allelic.PMID 9663658Read ↗

The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis.Semantic proximity Read ↗

W-sash affects positive and negative elements controlling c-kit expression: ectopic c-kit expression at sites of kit-ligand expression affects melanogenesis.Semantic proximity Read ↗

Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W.Semantic proximity Read ↗

Conditional Deletion of Kit in Melanocytes: White Spotting Phenotype Is Cell Autonomous.Semantic proximity Read ↗

Long-range genomic rearrangements upstream of Kit dysregulate the developmental pattern of Kit expression in W57 and Wbanded mice and interfere with distinct steps in melanocyte development.Semantic proximity Read ↗

Instability at the W/c-kit locus in mice: analysis of melanocyte cell lines derived from reversion spots.Semantic proximity Read ↗

W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor.Semantic proximity Read ↗

Ectopic expression of a c-kitW42 minigene in transgenic mice: recapitulation of W phenotypes and evidence for c-kit function in melanoblast progenitors.Semantic proximity Read ↗

Phenotypic reversions at the W/Kit locus mediated by mitotic recombination in mice.Semantic proximity Read ↗

Mutations at the W locus affect survival of neural crest-derived melanocytes in the mouse.Semantic proximity Read ↗

Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism.Semantic proximity Read ↗

Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1.Semantic proximity Read ↗

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