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Article

P53 gene mutations in acute myeloid leukemia with 17p monosomy.

Blood - 1 Oct 1991

Fenaux P, Jonveaux P, Quiquandon I, Laï J L, Pignon J M, Loucheux-Lefebvre M H, Bauters F, Berger R, Kerckaert J P

Abstract excerpt

We looked for mutations of exons 5 to 8 of the P53 gene in 10 patients with acute myeloid leukemia (AML) and 17p monosomy, and 36 patients with AML and no cytogenetic abnormalities of 17p. DNA was analyzed by polymerase chain reaction, single-strand conformation polymorphism analysis, and nucleotide sequencing. Four of the 10 patients with 17p monosomy showed point mutation, single-nucleotide deletion, or...

Topics

Base Sequence
Chromosomes, Human, Pair 17
Exons
Genes, p53
Humans
Leukemia, Myeloid, Acute
Molecular Sequence Data
Monosomy
Mutation
Polymerase Chain Reaction
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 1912553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1912553-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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