Article
Analysis of the p53 gene mutations in acute myelogenous leukemia: the p53 gene mutations associated with a deletion of chromosome 17.
Annals of hematology - 1 Aug 1995
Kurosawa M, Okabe M, Kunieda Y, Asaka M
Abstract excerpt
In order to determine the relevance of the p53 tumor suppressor gene mutations in acute myelogenous leukemia (AML), we analyzed the p53 gene in genomic DNA of 18 unselected cases of AML by polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) and direct sequencing. We detected three cases (16.7%) with the p53 gene mutations showing only the mutant alleles; the high incidence in cases with...
Topics
- Base Sequence
- Chromosome Deletion
- Chromosomes, Human, Pair 17
- DNA
- Genes, p53
- Humans
- Leukemia, Myeloid, Acute
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational