Total loss of p53 DNA sequences in acute myeloid leukemia.

doi:10.1016/0145-2126(94)90011-6

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Article

Total loss of p53 DNA sequences in acute myeloid leukemia.

Leukemia research - 1 Jan 1994

Gandini D, Cuneo A, Carli M G, Lanza F, Castoldi G L, del Senno L

Abstract excerpt

Mutations of the p53 tumour suppressor gene on chromosome 17p are a common genetic change in the malignant progression of many cancers. Here we report a case of a 71-year-old man with haematological, cytofluorimetric and cytochemical findings consistent with a 'de novo' M2 acute myeloid leukaemia...

Topics

Aged
Alleles
Chromosomes, Human, Pair 17
DNA, Neoplasm
Gene Deletion
Genes, p53
Humans
Leukemia, Myeloid, Acute
Male

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