Article
Mutations of the P53 gene in acute myeloid leukaemia.
British journal of haematology - 1 Feb 1992
Fenaux P, Preudhomme C, Quiquandon I, Jonveaux P, Laï J L, Vanrumbeke M, Loucheux-Lefebvre M H, Bauters F, Berger R, Kerckaert J P
Abstract excerpt
In a previous report we found point mutations in exons 5-8 of the P53 gene in five of 46 patients with acute myeloid leukaemia (AML), with a predominance of mutations in the 10 patients with 17p monosomy. In this report we extended our findings studying such mutations in 66 unselected additional cases of AML, using polymerase chain reaction single strand conformation polymorphism (SSCP) analysis and nucleotide...
Topics
- Acute Disease
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Base Sequence
- Child
- DNA, Neoplasm
- Female
- Genes, p53
- Humans
- Leukemia, Myeloid