Article
Monosomal karyotype and chromosome 17p loss or TP53 mutations in decitabine-treated patients with acute myeloid leukemia.
Annals of hematology - 1 Jul 2020
Becker Heiko, Pfeifer Dietmar, Ihorst Gabriele, Pantic Milena, Wehrle Julius, Rüter Björn H, Bullinger Lars, Hackanson Björn, Germing Ulrich, Kuendgen Andrea, Platzbecker Uwe, Döhner Konstanze, Ganser Arnold, Hagemeijer Anne, Wijermans Pierre W, Döhner Hartmut, Duyster Justus, Lübbert Michael
Abstract excerpt
TP53 aberrations reportedly predict favorable responses to decitabine (DAC) in acute myeloid leukemia (AML). We evaluated clinical features and outcomes associated with chromosome 17p loss or TP53 gene mutations in older, unfit DAC-treated AML patients in a phase II trial. Of 178 patients, 25 had loss of 17p in metaphase cytogenetics; 24 of these had a complex (CK+) and 21 a monosomal karyotype (MK+). In analyses...
Topics
- Aged
- Aged, 80 and over
- Chromosome Deletion
- Chromosomes, Human, Pair 17
- Clonal Evolution
- DNA Mutational Analysis
- Decitabine
- Female
- Germany