Article
TP53 mutations emerge at early phase of myelodysplastic syndrome and are associated with complex chromosomal abnormalities.
Blood - 15 Apr 1995
Kaneko H, Misawa S, Horiike S, Nakai H, Kashima K
Abstract excerpt
We examined TP53 mutation in 57 patients with myelodysplastic syndrome (MDS) at either the MDS phase or at the terminal leukemic phase using polymerase chain reaction-mediated single-strand conformation polymorphism (PCR-SSCP) analysis. TP53 mutations within exons 5 through 8 were found in seven patients. All these mutations were detected at the presentation of MDS whether these patients showed leukemic...
Topics
- Acute Disease
- Adult
- Aged
- Aged, 80 and over
- Base Sequence
- Blast Crisis
- Bone Marrow
- Chromosome Aberrations
- Chromosomes, Human, Pair 17
- Disease Progression
- Female