Article
Copy number neutral loss of heterozygosity at 17p and homozygous mutations of TP53 are associated with complex chromosomal aberrations in patients newly diagnosed with myelodysplastic syndromes.
Leukemia research - 1 Mar 2016
Svobodova Karla, Zemanova Zuzana, Lhotska Halka, Novakova Milena, Podskalska Lucie, Belickova Monika, Brezinova Jana, Sarova Iveta, Izakova Silvia, Lizcova Libuse, Berkova Adela, Siskova Magda, Jonasova Anna, Cermak Jaroslav, Michalova Kyra
Abstract excerpt
Complex karyotypes are seen in approximately 20% of patients with myelodysplastic syndromes (MDS) and are associated with a high risk of transformation to acute myeloid leukemia and poor outcomes in patients. Copy number neutral loss of heterozygosity (CN-LOH, i.e., both copies of a chromosomal pair or their parts originate from one parent) might contribute to increased genomic instability in the bone-marrow...
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