Article
Incidence of 17p deletions and TP53 mutation in myelodysplastic syndrome and acute myeloid leukemia with 5q deletion.
Genes, chromosomes & cancer - 1 Dec 2012
Sebaa Amel, Ades Lionel, Baran-Marzack Fanny, Mozziconacci Marie-Joelle, Penther Dominique, Dobbelstein Sophie, Stamatoullas Aspasia, Récher Christian, Prebet Thomas, Moulessehoul Soraya, Fenaux Pierre, Eclache Virginie
Abstract excerpt
TP53 mutations are frequent in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) with complex karyotype that include del(5q) and are often associated with deletion of 17p. They have also recently been observed in MDS with isolated del(5q). We assessed the incidence of 17p deletion detected by fluorescence in situ hybridization (FISH) and of TP53 mutations detected by direct sequencing and their...
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