Article
The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification.
International journal of cancer - 1 May 2009
Sohn Kyoung-Jin, Jang Hyeran, Campan Mihaela, Weisenberger Daniel J, Dickhout Jeffrey, Wang Yi-Cheng, Cho Robert C, Yates Zoe, Lucock Mark, Chiang En-Pei, Austin Richard C, Choi Sang-Woon, Laird Peter W, Kim Young-In
Abstract excerpt
The C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with a decreased risk of colon cancer although it may increase the risk of breast cancer. This polymorphism is associated with changes in intracellular folate cofactors, which may affect DNA methylation and synthesis via altered one-carbon transfer reactions. We investigated the effect of this mutation on DNA methylation...
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