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Modeling folate, one-carbon metabolism, and DNA methylation

29 Jul 2008

Abstract excerpt

The B-vitamin folate is essential for one-carbon transfer reactions. These include methylation reactions, such as the methylation of DNA or other substrates (by use of S-adenosylmethionine, SAM, which is concurrently converted to S-adenosylhomocysteine), and also the synthesis of thymidine and purines, which are needed for DNA synthesis and repair (see Figure 1).1 A protective role of folate early in...

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PMID: 18673484
DOI: 10.1111/j.1753-4887.2008.00062.x

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