Article
A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer.
Cancer research - 15 Mar 2003
Heijmans Bastiaan T, Boer Jolanda M A, Suchiman H Eka D, Cornelisse Cees J, Westendorp Rudi G J, Kromhout Daan, Feskens Edith J M, Slagboom P Eline
Abstract excerpt
Folate metabolism is thought to play an important role in carcinogenesis through its involvement in both DNA methylation and nucleotide synthesis. A common Ala(222)/Val variant in the methylenetetrahydrofolate reductase (MTHFR) gene leads to a disturbed folate metabolism and is associated with decreased genomic DNA methylation. We previously reported that the MTHFR Val/Val genotype was associated with increased...
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