Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate.

Journal of the National Cancer Institute - 21 Jan 2004

Sohn Kyoung-Jin, Croxford Ruth, Yates Zoe, Lucock Mark, Kim Young-In

Abstract excerpt

BACKGROUND: Although single nucleotide polymorphisms may be potentially important pharmacogenetic determinants of cancer therapy, functional evidence regarding their relevance is currently lacking. The C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with c...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimetabolites, Antineoplastic
Share to Cytosine
Share to Leucovorin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methotrexate

Share to Random Allocation

Share to Thymidylate Synthase

Share to Thymine

Share to Transplantation, Heterologous

Source

Identifiers

PMID: 14734703
DOI: 10.1093/jnci/djh015

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14734703-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate.PMID 14734703Read ↗

Role of the MTHFR polymorphisms in cancer risk modification and treatment.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase (MTHFR) variants and fluorouracil-based treatments in colorectal cancer.Semantic proximity Read ↗

Functional polymorphisms of folate metabolism and response to chemotherapy for colorectal cancer, a systematic review and meta-analysis.Semantic proximity Read ↗

The Impact of Thymidylate Synthase and Methylenetetrahydrofolate Reductase Genotypes on Sensitivity to 5-Fluorouracil Treatment in Colorectal Cancer Cells.Semantic proximity Read ↗

The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification.Semantic proximity Read ↗

5,10-Methylenetetrahydrofolate reductase polymorphisms and pharmacogenetics: a new role of single nucleotide polymorphisms in the folate metabolic pathway in human health and disease.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase gene polymorphisms and response to fluorouracil-based treatment in advanced colorectal cancer patientsSemantic proximity Read ↗

Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase and breast cancer chemotherapy response.Semantic proximity Read ↗

5‐Fluorouracil‐based chemotherapy for colorectal cancer and MTHFR/MTRR genotypesSemantic proximity Read ↗

Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms: relationships with 5-fluorouracil sensitivitySemantic proximity Read ↗

Methylenetetrahydrofolate reductase genetic polymorphisms and toxicity to 5-FU-based chemoradiation in rectal cancer.Semantic proximity Read ↗

Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.