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Article

Regulation of Folate-Mediated One-Carbon Metabolism by Glycine N-Methyltransferase (GNMT) and Methylenetetrahydrofolate Reductase (MTHFR).

Journal of nutritional science and vitaminology - 1 Jan 2015

Wang Yi-Cheng, Wu Ming-Tsung, Lin Yan-Jun, Tang Feng-Yao, Ko Hsin-An, Chiang En-Pei

Abstract excerpt

Folate-mediated one-carbon metabolism is an important therapeutic target of human diseases. We extensively investigated how gene-nutrient interactions may modulate human cancer risk in 2 major folate metabolic genes, MTHFR and GNMT. The biochemical impacts of MTHFR and GNMT on methyl group supply, global DNA methylation, nucleotide biosynthesis, DNA damage, and partitioning of the folate dependent 1-carbon group...

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Source

Identifiers

PMID: 26598833
DOI: 10.3177/jnsv.61.S148

Genes

GNMT
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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