Article
Role of the MTHFR polymorphisms in cancer risk modification and treatment.
Future oncology (London, England) - 1 May 2009
Kim Young-In
Abstract excerpt
The role of folate, a water-soluble B vitamin, and single nucleotide polymorphisms (SNPs) in the folate metabolic pathway in human health and disease has been rapidly expanding. Recently, functionally significant SNPs in 5,10-methylenetetrahydrofolate reductase (MTHFR), a critical enzyme for intracellular folate homeostasis and metabolism, have been identified and characterized. The MTHFR SNPs are ideal...
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