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Article

One-carbon metabolism, MTHFR polymorphisms, and risk of breast cancer.

Cancer research - 15 Feb 2005

Chen Jia, Gammon Marilie D, Chan Wendy, Palomeque Caroline, Wetmur James G, Kabat Geoffrey C, Teitelbaum Susan L, Britton Julie A, Terry Mary Beth, Neugut Alfred I, Santella Regina M

Abstract excerpt

Accumulating evidence from epidemiologic studies suggests that risk of breast cancer is reduced in relation to increased consumption of folate and related B vitamins. We investigated independent and joint effects of B vitamin intake as well as two polymorphisms of a key one-carbon metabolizing gene [i.e., methylenetetrahydrofolate reductase (MTHFR) 677C>T and 1298A>C] on breast cancer risk. The study uses the...

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Identifiers

PMID: 15735051
DOI: 10.1158/0008-5472.CAN-04-2630

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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