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Article

Functional allelic heterogeneity and pleiotropy of a repeat polymorphism in tyrosine hydroxylase: prediction of catecholamines and response to stress in twins.

Physiological genomics - 17 Nov 2004

Zhang Lian, Rao Fangwen, Wessel Jennifer, Kennedy Brian P, Rana Brinda K, Taupenot Laurent, Lillie Elizabeth O, Cockburn Myles, Schork Nicholas J, Ziegler Michael G, O'Connor Daniel T

Abstract excerpt

Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, has a common tetranucleotide repeat polymorphism, (TCAT)(n). We asked whether variation at (TCAT)(n) may influence the autonomic nervous system and its response to environmental stress. To understand the role of heredity in such traits, we turned to a human twin study design. Both biochemical and physiological autonomic traits displayed...

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Identifiers

PMID: 15367723
DOI: 10.1152/physiolgenomics.00151.2004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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