Article
A functional intronic variant in the tyrosine hydroxylase (TH) gene confers risk of essential hypertension in the Northern Chinese Han population.
Clinical science (London, England : 1979) - 1 Sept 2008
Wang Laiyuan, Li Biao, Lu Xiangfeng, Zhao Qi, Li Yun, Ge Dongliang, Li Hongfan, Zhang Penghua, Chen Shufeng, Chen Runsheng, Qiang Boqin, Gu Dongfeng
Abstract excerpt
The TH (tyrosine hydroxylase) gene encodes the rate-limiting enzyme of catecholamine biosynthesis, and is involved in the pathogenesis of hypertension, but the relationship of its variants with hypertension has not been extensively studied. We designed a case-controlled study consisting of 503 HT (hypertensive) individuals and 490 NT (normotensive) individuals matched by region, age and gender to systematically...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.