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Article

Human tyrosine hydroxylase natural allelic variation: influence on autonomic function and hypertension.

Cellular and molecular neurobiology - 1 Nov 2010

Rao Fangwen, Zhang Kuixing, Zhang Lian, Rana Brinda K, Wessel Jennifer, Fung Maple M, Rodriguez-Flores Juan L, Taupenot Laurent, Ziegler Michael G, O'Connor Daniel T

Abstract excerpt

The catecholamine biosynthetic pathway consists of several enzymatic steps in series, beginning with the amino acids phenylalanine and tyrosine, and eventuating in the catecholamines norepinephrine (noradrenaline) and epinephrine (adrenaline). Since the enzyme tyrosine hydroxylase (TH; tyrosine 3-mono-oxygenase; EC 1.14.16.2; chromosome 11p15.5) is generally considered to be rate-limiting in this pathway, probed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20571875
DOI: 10.1007/s10571-010-9535-7
PMCID: PMC3008933

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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