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Article

Biallelic, ubiquitous transcription from the distal germline Ig{kappa} locus promoter during B cell development.

Proceedings of the National Academy of Sciences of the United States of America - 13 Jan 2009

Amin Rupesh H, Cado Dragana, Nolla Hector, Huang Dan, Shinton Susan A, Zhou Yan, Hardy Richard R, Schlissel Mark S

Abstract excerpt

Allelic exclusion of Ig gene expression is necessary to limit the number of functional receptors to one per B cell. The mechanism underlying allelic exclusion is unknown. Because germline transcription of Ig and TCR loci is tightly correlated with rearrangement, we created two novel knock-in mice that report transcriptional activity of the Jkappa germline promoters in the Igkappa locus. Analysis of these mice...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Immunoglobulin kappa-Chains

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Source

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Identifiers

PMID: 19116268
DOI: 10.1073/pnas.0808895106
PMCID: PMC2626736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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