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Article

Transcriptional regulation of the Ikzf1 locus

4 Sept 2013

Abstract excerpt

Ikaros is a critical regulator of lymphocyte development and homeostasis; thus, understanding its transcriptional regulation is important from both developmental and clinical perspectives. Using a mouse transgenic reporter approach, we functionally characterized a network of highly conserved cis-acting elements at the Ikzf1 locus. We attribute B-cell and myeloid but not T-cell specificity to the main Ikzf1...

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Identifiers

PMID: 24002445
DOI: 10.1182/blood-2013-01-474916

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