Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biallelic germline transcription at the kappa immunoglobulin locus.

The Journal of experimental medicine - 17 Mar 2003

Singh Nandita, Bergman Yehudit, Cedar Howard, Chess Andrew

Abstract excerpt

Rearrangement of antigen receptor genes generates a vast array of antigen receptors on lymphocytes. The establishment of allelic exclusion in immunoglobulin genes requires differential treatment of the two sequence identical alleles. In the case of the kappa immunoglobulin locus, changes in chromatin structure, methylation, and replication timing of the two alleles are all potentially involved in regulating...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to beta 2-Microglobulin
Share to Bone Marrow Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Lineage

Share to Gene Rearrangement

Share to Genes, Immunoglobulin

Share to Immunoglobulin kappa-Chains

Share to In Situ Hybridization, Fluorescence

Source

Open in PubMed Open full text

Identifiers

PMID: 12629064
DOI: 10.1084/jem.20021392
PMCID: PMC2193856

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biallelic germline transcription at the kappa immunoglobulin locus.PMID 12629064Read ↗

Biallelic, ubiquitous transcription from the distal germline Ig{kappa} locus promoter during B cell development.Semantic proximity Read ↗

Variegated transcriptional activation of the immunoglobulin kappa locus in pre-b cells contributes to the allelic exclusion of light-chain expression.Semantic proximity Read ↗

Re-organization of the immunoglobulin kappa gene on both alleles is not an obligatory prerequisite for Ig lambda gene expression in human cells.Semantic proximity Read ↗

Germline transcription from T-cell receptor Vbeta gene is uncoupled from allelic exclusion.Semantic proximity Read ↗

Clonal allelic predetermination of immunoglobulin-κ rearrangement.Semantic proximity Read ↗

Induced kappa receptor editing shows no allelic preference in a mouse pre-B cell line.Semantic proximity Read ↗

Epigenetic ontogeny of the Igk locus during B cell development.Semantic proximity Read ↗

Asynchronous replication and allelic exclusion in the immune system.Semantic proximity Read ↗

A reappraisal of evidence for probabilistic models of allelic exclusion.Semantic proximity Read ↗

RNA surveillance down-regulates expression of nonfunctional kappa alleles and detects premature termination within the last kappa exon.Semantic proximity Read ↗

Novel recombinations of the IG kappa-locus that result in allelic exclusion.Semantic proximity Read ↗

A targeted deletion of a region upstream from the Jkappa cluster impairs kappa chain rearrangement in cis in mice and in the 103/bcl2 cell line.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.