Article
A reappraisal of evidence for probabilistic models of allelic exclusion.
Proceedings of the National Academy of Sciences of the United States of America - 13 Jan 2009
Taylor Benjamin, Cobb Bradley S, Bruno Ludovica, Webster Zoe, Fisher Amanda G, Merkenschlager Matthias
Abstract excerpt
B cell development requires the coordinated rearrangement of Ig heavy (IgH) and light chain loci (IgL). Most mature B cells express a single B cell receptor of unique specificity, and a central question in immunology concerns the mechanisms that prevent the productive rearrangement of >1 IgH and IgL allele per cell. Probabilistic models of allelic exclusion maintain that simultaneous rearrangement of both alleles...
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