The Ig(kappa) enhancer influences the ratio of Ig(kappa) versus Ig(lambda) B lymphocytes.

doi:10.1016/s1074-7613(00)80319-2

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Article

The Ig(kappa) enhancer influences the ratio of Ig(kappa) versus Ig(lambda) B lymphocytes.

Immunity - 1 Sept 1996

Gorman J R, van der Stoep N, Monroe R, Cogne M, Davidson L, Alt F W

Abstract excerpt

We generated mice harboring germline mutations in which the enhancer element located 9 kb 3' of the immunoglobulin kappa light chain gene (3'E kappa) was replaced either by a single loxP site (3'E kappa delta) or by a neomycin resistance gene (3'E kappa N). Mice homozygous for the 3'E(kappa delta...

Topics

Animals
B-Lymphocytes
Enhancer Elements, Genetic
Female
Gene Rearrangement
Genes, Immunoglobulin
Immunoglobulin kappa-Chains
Immunoglobulin lambda-Chains
Mice
Mice, Inbred C57BL
Mutation

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