Article
The Ig(kappa) enhancer influences the ratio of Ig(kappa) versus Ig(lambda) B lymphocytes.
Immunity - 1 Sept 1996
Gorman J R, van der Stoep N, Monroe R, Cogne M, Davidson L, Alt F W
Abstract excerpt
We generated mice harboring germline mutations in which the enhancer element located 9 kb 3' of the immunoglobulin kappa light chain gene (3'E kappa) was replaced either by a single loxP site (3'E kappa delta) or by a neomycin resistance gene (3'E kappa N). Mice homozygous for the 3'E(kappa delta) mutation had substantially reduced numbers of kappa-expressing B cells and increased numbers of lambda-expressing B...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.