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Article

Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in kappa transgenic mice.

Nature - 1 Jan 2000

Ritchie K A, Brinster R L, Storb U

Abstract excerpt

Hybridomas were produced from spleen cells of kappa transgenic mice to investigate expression of the transgenic kappa gene, its effect on allelic exclusion and its effect on the control of light-chain gene rearrangement and expression. Our results show that the transgene is expressed normally and that the production of a complete immunoglobulin molecule turns off light-chain gene rearrangement.

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PMID: 6438533
DOI: 10.1038/312517a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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