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Article

Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in kappa transgenic mice.

Nature - 1 Jan 2000

Ritchie K A, Brinster R L, Storb U

Abstract excerpt

Hybridomas were produced from spleen cells of kappa transgenic mice to investigate expression of the transgenic kappa gene, its effect on allelic exclusion and its effect on the control of light-chain gene rearrangement and expression. Our results show that the transgene is expressed normally and that the production of a complete immunoglobulin molecule turns off light-chain gene rearrangement.

Topics

Alleles
Animals
B-Lymphocytes
Base Sequence
Gene Expression Regulation
Genes
Genetic Engineering
Hybridomas
Immunoglobulin Light Chains
Immunoglobulin kappa-Chains
Mice
Recombination, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcription, Genetic

Source

Identifiers

PMID: 6438533
DOI: 10.1038/312517a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-6438533-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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