Regulation of the Igk locus and B cell development

Abstract excerpt

Allelic exclusion coupled to lineage and stage specific regulation ensure the Igk locus undergoes RAG mediated V-J recombination only at the small pre-BII stage of lymphocyte development. These mechanisms also ensure the final antigen receptor is monospecific and allow self-specific receptors to be recognised and altered at later stages of development. Allelic exclusion is controlled by mechanism involving either...

Topics

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• B-Lymphocytes
• Bone Marrow Cells
• Gene Rearrangement
• Immunoglobulin Heavy Chains
• Immunoglobulin Light Chains
• Immunoglobulins
• Models, Statistical
• Receptors, Antigen, B-Cell

Identifiers and source

Literature Corpus work

4cad3108-d0a8-556d-958c-8925a98cd09b

DOI

10.25560/4395