Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induced kappa receptor editing shows no allelic preference in a mouse pre-B cell line.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2000

Liu X, Linden M, Van Ness B

Abstract excerpt

B cell Ag receptor editing is a process that can change kappa antigen recognition specificity of a B cell receptor through secondary gene rearrangements on the same allele. In this study we used a model mouse pre-B cell line (38B9) to examine factors that might affect allelic targeting of secondary rearrangements of the kappa locus. We isolated clones that showed both productive and nonproductive rearrangements...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clone Cells
Share to Gene Rearrangement, B-Lymphocyte, Light Chain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hematopoietic Stem Cells

Share to Immunoglobulin J-Chains

Share to Immunoglobulin kappa-Chains

Share to Immunoglobulin mu-Chains

Share to Immunoglobulin Variable Region

Share to Receptors, Antigen, B-Cell

Source

Identifiers

PMID: 11120834
DOI: 10.4049/jimmunol.165.12.7058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induced kappa receptor editing shows no allelic preference in a mouse pre-B cell line.PMID 11120834Read ↗

Receptor editing in peripheral B cell tolerance.Semantic proximity Read ↗

Split tolerance in peripheral B cell subsets in mice expressing a low level of Igkappa-reactive ligand.Semantic proximity Read ↗

Editing disease-associated autoantibodies.Semantic proximity Read ↗

Consequences of receptor editing at the lambda locus: multireactivity and light chain secretion.Semantic proximity Read ↗

The efficiency of B cell receptor (BCR) editing is dependent on BCR light chain rearrangement status.Semantic proximity Read ↗

Corrective recombination of mouse immunoglobulin kappa alleles in Abelson murine leukemia virus-transformed pre-B cells.Semantic proximity Read ↗

Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in kappa transgenic mice.Semantic proximity Read ↗

Biallelic, ubiquitous transcription from the distal germline Ig{kappa} locus promoter during B cell development.Semantic proximity Read ↗

Allelic and isotypic light chain inclusion in peripheral B cells from anti-DNA antibody transgenic C57BL/6 and BALB/c mice.Semantic proximity Read ↗

A targeted deletion of a region upstream from the Jkappa cluster impairs kappa chain rearrangement in cis in mice and in the 103/bcl2 cell line.Semantic proximity Read ↗

Peripheral B cell receptor editing may promote the production of high-affinity autoantibodies in CD22-deficient mice.Semantic proximity Read ↗

A targeted kappa immunoglobulin gene containing a deletion of the nuclear matrix association region exhibits spontaneous hyper-recombination in pre-B cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.