Article
Induced kappa receptor editing shows no allelic preference in a mouse pre-B cell line.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2000
Liu X, Linden M, Van Ness B
Abstract excerpt
B cell Ag receptor editing is a process that can change kappa antigen recognition specificity of a B cell receptor through secondary gene rearrangements on the same allele. In this study we used a model mouse pre-B cell line (38B9) to examine factors that might affect allelic targeting of secondary rearrangements of the kappa locus. We isolated clones that showed both productive and nonproductive rearrangements...
Topics
- Alleles
- Animals
- B-Lymphocytes
- Cell Line
- Clone Cells
- Gene Rearrangement, B-Lymphocyte, Light Chain
- Hematopoietic Stem Cells
- Immunoglobulin J-Chains
- Immunoglobulin Variable Region
- Immunoglobulin kappa-Chains
- Immunoglobulin mu-Chains
- Mice
- Receptors, Antigen, B-Cell