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Article

Genetic-epigenetic interaction modulates μ-opioid receptor regulation.

Human molecular genetics - 1 Nov 2012

Oertel Bruno G, Doehring Alexandra, Roskam Bianca, Kettner Mattias, Hackmann Nadja, Ferreirós Nerea, Schmidt Peter H, Lötsch Jörn

Abstract excerpt

Genetic and epigenetic mechanisms play important roles in protein expression, although at different levels. Genetic variations can alter CpG sites and thus influence the epigenetic regulation of mRNA expression, providing an increasingly recognized mechanism of functional consequences of genetic polymorphisms. One of those genetic effects is the association of reduced μ-opioid receptor expression with the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22875838
DOI: 10.1093/hmg/dds314

Genes

OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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