Article
A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signaling.
The Journal of biological chemistry - 2 Feb 2001
Befort K, Filliol D, Decaillot F M, Gaveriaux-Ruff C, Hoehe M R, Kieffer B L
Abstract excerpt
Large scale sequencing of the human mu-opioid receptor (hMOR) gene has revealed polymorphic mutations that occur within the coding region. We have investigated whether the mutations N40D in the extracellular N-terminal region, N152D in the third transmembrane domain, and R265H and S268P in the third intracellular loop alter functional properties of the receptor expressed in mammalian cells. The N152D receptor was...
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