Article
Genotype/phenotype analyses for 53 Crohn's disease associated genetic polymorphisms.
PloS one - 1 Jan 2012
Jung Camille, Colombel Jean-Frédéric, Lemann Marc, Beaugerie Laurent, Allez Matthieu, Cosnes Jacques, Vernier-Massouille Gwenola, Gornet Jean-Marc, Gendre Jean-Pierre, Cezard Jean-Pierre, Ruemmele Frank M, Turck Dominique, Merlin Françoise, Zouali Habib, Libersa Christian, Dieudé Philippe, Soufir Nadem, Thomas Gilles, Hugot Jean-Pierre
Abstract excerpt
BACKGROUND & AIMS: Recent studies reported a role for more than 70 genes or loci in the susceptibility to Crohn's disease (CD). However, the impact of these associations in clinical practice remains to be defined. The aim of the study was to analyse the relationship between genotypes and phenotypes for the main 53 CD-associated polymorphisms. METHOD: A cohort of 798 CD patients with a median follow up of 7 years...
Topics
- Adolescent
- Adult
- Age of Onset
- Case-Control Studies
- Cohort Studies
- Crohn Disease
- Female
- Genotyping Techniques
- Humans
- Male