Article
Human induced pluripotent stem cells from two azoospermic patients with Klinefelter syndrome show similar X chromosome inactivation behavior to female pluripotent stem cells.
Human reproduction (Oxford, England) - 1 Nov 2019
Panula Sarita, Kurek Magdalena, Kumar Pankaj, Albalushi Halima, Padrell Sánchez Sara, Damdimopoulou Pauliina, Olofsson Jan I, Hovatta Outi, Lanner Fredrik, Stukenborg Jan-Bernd
Abstract excerpt
STUDY QUESTION: Does the X chromosome inactivation (XCI) of Klinefelter syndrome (KS)-derived human induced pluripotent stem cells (hiPSCs) correspond to female human pluripotent stem cells (hPSCs) and reflect the KS genotype? SUMMARY ANSWER: Our results demonstrate for the first time that KS-derived hiPSCs show similar XCI behavior to female hPSCs in culture and show biological relevance to KS genotype-related...
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