Article
No effect of MDR1 C3435T polymorphism on oral pharmacokinetics of telmisartan in 19 healthy Chinese male subjects.
Clinical chemistry and laboratory medicine - 1 Jan 2009
Guo Xin, Chen Xiao-Ping, Cheng Ze-Neng, Luo Xi, Guo Ren, Chen Lei, Chen Jie, Chen Bo, Peng Jun, Li Yuan-Jian
Abstract excerpt
BACKGROUND: Considerable interindividual differences in both drug response and pharmacokinetics of telmisartan have been identified. This study was designed to investigate the influence of MDR1 C3435T polymorphism on pharmacokinetics of telmisartan after a single oral dose in healthy Chinese volunteers. METHODS: A total of 61 unrelated male volunteers were genotyped for MDR1 C3435T polymorphism by using the...
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