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Pharmacokinetic and pharmacogenomic profiles of telmisartan after the oral microdose and therapeutic dose.

Pharmacogenetics and genomics - 1 Aug 2011

Ieiri Ichiro, Nishimura Chisa, Maeda Kazuya, Sasaki Tomohiro, Kimura Miyuki, Chiyoda Takeshi, Hirota Tekeshi, Irie Shin, Shimizu Hitoshi, Noguchi Takanori, Yoshida Kenji, Sugiyama Yuichi

Abstract excerpt

OBJECTIVES: In this study, we evaluated (a) the contribution of SLCO1B3 and UGT1A polymorphisms to the pharmacokinetics of telmisartan in two forms, a microdose (MD) and a therapeutic dose (TD); (b) linkage disequilibrium (LD) between UGT1A1 and UGT1A3; and (c) linearity in the pharmacokinetics of telmisartan between the two forms. METHODS: Telmisartan was orally administered at MD condition (100 μg), and then at...

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PMID: 21691256
DOI: 10.1097/FPC.0b013e3283489ce2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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