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UGT1A3 and Sex Are Major Determinants of Telmisartan Pharmacokinetics-A Comprehensive Pharmacogenomic Study.

Clinical pharmacology and therapeutics - 1 Oct 2020

Hirvensalo Päivi, Tornio Aleksi, Launiainen Terhi, Paile-Hyvärinen Maria, Tapaninen Tuija, Neuvonen Mikko, Backman Janne T, Niemi Mikko

Abstract excerpt

To investigate how variability in multiple pharmacokinetic genes associates with telmisartan exposure, we determined telmisartan single-dose (40 mg) pharmacokinetics and sequenced 379 genes in 188 healthy volunteers. Intronic UGT1A variants showed the strongest associations with the area under the plasma concentration-time curve from zero hours to infinity (AUC0-∞ ) and peak plasma concentration (Cmax ) of...

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PMID: 32498119
DOI: 10.1002/cpt.1928

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