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The impact of pharmacogenetics of metabolic enzymes and transporters on the pharmacokinetics of telmisartan in healthy volunteers.

Pharmacogenetics and genomics - 1 Sept 2011

Yamada Akihiro, Maeda Kazuya, Ishiguro Naoki, Tsuda Yasuhiro, Igarashi Takashi, Ebner Thomas, Roth Willy, Ikushiro Shinichi, Sugiyama Yuichi

Abstract excerpt

OBJECTIVE: Telmisartan is mainly taken up into the liver by organic anion transporting polypeptide (OATP) 1B3, conjugated with glucuronate, and excreted into the bile. We investigated the relationship between genotypes of metabolizing enzymes and transporters and pharmacokinetics of telmisartan in clinical study. We also checked which enzymes are responsible for telmisartan glucuronidation. MATERIALS AND METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21829131
DOI: 10.1097/FPC.0b013e3283482502

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