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Article

Polymorphism of ORM1 is associated with the pharmacokinetics of telmisartan.

PloS one - 1 Jan 2013

Chen Wang-Qing, Shu Yan, Li Qing, Xu Lin-Yong, Roederer Mary W, Fan Lan, Wu Lan-Xiang, He Fa-Zhong, Luo Jian-Quan, Tan Zhi-Rong, He Yi-Jing, Zhou Hong-Hao, Chen Xiang, Zhang Wei

Abstract excerpt

BACKGROUND: The pharmacokinetics (PKs) and pharmacodynamics (PDs) of telmisartan varies among the individuals, and the main causes remain unknown. The aim of this study was to evaluate the impact of ORM1, as well as ABCC2, ABCB1, ABCG2 and SLCO1B3 polymorphisms, on the disposition of the drug and BP change after taking 40 mg telmisartan in 48 healthy Chinese males. METHOD: A total of 48 healthy males were...

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Source

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Identifiers

PMID: 23940561
DOI: 10.1371/journal.pone.0070341
PMCID: PMC3734062

Genes

ORM1
ABCC2
ABCB1
ABCG2
DBP
TNC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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