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Article

Effect of CYP3A41G, CYP3A53, POR*28, and ABCB1 C3435T on the pharmacokinetics of nifedipine in healthy Chinese volunteers.

International journal of clinical pharmacology and therapeutics - 1 Sept 2015

Wang Xiao-Fei, Yan Liang, Cao Hui-Min, Wei Lu-Man, Yang Wei-Hong, Zhang Sheng-Jun, Zhang Li-Rong

Abstract excerpt

OBJECTIVE: Nifedipine is a calcium channel blocker that is widely used in the treatment of cardiovascular disease. However, significant individual variances in the disposition of nifedipine have been reported, and genetic factors are considered to play an important role. The aim of the present study was to investigate the effect of CYP3A4*1G, CYP3A5*3, ABCB1-C3435T, and POR*28 genetic polymorphisms on nifedipine...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP3A

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Share to NADPH-Ferrihemoprotein Reductase

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Source

Identifiers

PMID: 26104034
DOI: 10.5414/CP202211

Genes

POR
ABCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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