Article
Effects of genetic variants in UGT1A1, SLCO1B3, ABCB1, ABCC2, ABCG2, ORM1 on PK/PD of telmisartan in Chinese patients with mild to moderate essential hypertension .
International journal of clinical pharmacology and therapeutics - 1 Aug 2017
Pei Qi, Yang Liu, Tan Hong-Yi, Liu Shi-Kun, Liu Yang, Huang Lu, Li Rong-Hui, Wan Qian, Huang Jie, Guo Cheng-Xian, Zuo Xiao-Cong, Li Jingle, Yang Guo-Ping
Abstract excerpt
PURPOSE: This study aimed to understand the effects of single nucleotide polymorphisms (SNPs) in UGT1A1, SLCO1B3, ABCB1, ABCC2, ABCG2, and ORM1 on the pharmacokinetics (PK) (plasma concentration) and pharmacodynamics (PD) (blood pressure) of telmisartan in Chinese patients. METHODS: 58 Han Chinese patients (aged 45 - 72 years) with mild to moderate essential hypertension were included and received 80 mg/day...
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