Impact of interacting functional variants in COMT on regional gray matter volume in human brain.

doi:10.1016/j.neuroimage.2008.10.064

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Impact of interacting functional variants in COMT on regional gray matter volume in human brain.

NeuroImage - 1 Mar 2009

Honea Robyn, Verchinski Beth A, Pezawas Lukas, Kolachana Bhaskar S, Callicott Joseph H, Mattay Venkata S, Weinberger Daniel R, Meyer-Lindenberg Andreas

Abstract excerpt

BACKGROUND: Functional variants in the catechol-O-methyltransferase (COMT) gene have been shown to impact cognitive function, cortical physiology and risk for schizophrenia. A recent study showed that previously reported effects of the functional val158met SNP (rs4680) on brain function are modified by other functional SNPs and haplotypes in the gene, though it was unknown if these effects are also seen in brain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catechol O-Methyltransferase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Hippocampus

Share to Imaging, Three-Dimensional

Share to Magnetic Resonance Imaging

Share to Neurons

Share to Prefrontal Cortex

Share to Statistics as Topic

Source

Open in PubMed Open full text

Identifiers

PMID: 19071221
DOI: 10.1016/j.neuroimage.2008.10.064
PMCID: PMC2702693

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of interacting functional variants in COMT on regional gray matter volume in human brain.PMID 19071221Read ↗

Genetic Variation in the Catechol-O-Methyl Transferase Val108/158Met Is Linked to the Caudate and Posterior Cingulate Cortex Volume in Healthy Subjects: Voxel-Based Morphometry Analysis of Brain Magnetic Resonance Imaging.Semantic proximity Read ↗

Impact of complex genetic variation in COMT on human brain function.Semantic proximity Read ↗

COMT Val158Met × SLC6A4 5-HTTLPR interaction impacts on gray matter volume of regions supporting emotion processing.Semantic proximity Read ↗

Impact of catechol-O-methyltransferase Val(108/158) Met genotype on hippocampal and prefrontal gray matter volume.Semantic proximity Read ↗

ZNF804A rs1344706 interacts with COMT rs4680 to affect prefrontal volume in healthy adults.Semantic proximity Read ↗

Effects of COMT polymorphisms on brain function and behavior in health and disease.Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT) influences the connectivity of the prefrontal cortex at rest.Semantic proximity Read ↗

The COMT val158met polymorphism and brain morphometry in healthy young adults.Semantic proximity Read ↗

Opposite effects of catechol-O-methyltransferase Val158Met on cortical function in healthy subjects and patients with schizophrenia.Semantic proximity Read ↗

Modulative effects of COMT haplotype on age-related associations with brain morphology.Semantic proximity Read ↗

Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia.Semantic proximity Read ↗

Relationship of catechol-O-methyltransferase variants to brain structure and function in a population at high risk of psychosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.