Modulative effects of COMT haplotype on age-related associations with brain morphology.

doi:10.1002/hbm.23161

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Article

Modulative effects of COMT haplotype on age-related associations with brain morphology.

Human brain mapping - 1 Jun 2016

Lee Annie, Qiu Anqi

Abstract excerpt

Catechol-O-methyltransferase (COMT), located on chromosome 22q11.2, encodes an enzyme critical for dopamine flux in the prefrontal cortex. Genetic variants of COMT have been suggested to functionally manipulate prefrontal morphology and function in healthy adults. This study aims to investigate modulative roles of individuals COMT SNPs (rs737865, val158met, rs165599) and its haplotypes in age-related brain...

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Identifiers

PMID: 26920810
DOI: 10.1002/hbm.23161
PMCID: PMC6867428

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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