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Article

ZNF804A rs1344706 interacts with COMT rs4680 to affect prefrontal volume in healthy adults.

Brain imaging and behavior - 1 Feb 2018

Xu Qiang, Xiong Yongqin, Yuan Congcong, Liu Feng, Zhao Fangshi, Shen Junlin, Qin Wen, Yu Chunshui

Abstract excerpt

The biological function of ZNF804A rs1344706, the first genome-wide supported risk variant of schizophrenia, remains largely unknown. Based on the upregulating effect of ZNF804A on the expression of COMT, we hypothesize that ZNF804A may affect grey matter volume (GMV) by interacting with COMT. Voxel-based morphometry was applied to analyze the main and interaction effects of ZNF804A rs1344706 and COMT rs4680 on...

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Source

Identifiers

PMID: 28078547
DOI: 10.1007/s11682-016-9671-x

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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