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Article

A toll-like receptor 4 variant is associated with fatal outcome in children with invasive meningococcal disease.

Acta paediatrica (Oslo, Norway : 1992) - 1 Mar 2009

Faber Joerg, Henninger Nicole, Finn Adam, Zenz Werner, Zepp Fred, Knuf Markus

Abstract excerpt

AIMS: Toll-like receptor 4 (TLR4) is the major endotoxin signalling receptor of the innate immune system and is required for efficient recognition of bacterial infections. Here, we analysed a possible association between the TLR4 variant Asp299Gly and disease outcome in children with invasive meningococcal disease. METHODS: In total, 197 children with invasive meningococcal disease were analysed for the TLR4...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19067670
DOI: 10.1111/j.1651-2227.2008.01163.x

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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