Article
Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome.
Biochemical Society transactions - 1 Jun 2003
Child N J A, Yang I A, Pulletz M C K, de Courcy-Golder K, Andrews A-L, Pappachan V J, Holloway J W
Abstract excerpt
The systemic inflammatory response syndrome (SIRS) is a major cause of morbidity and mortality, and is thought to be due to an over-amplification of an inflammatory response. The Toll-like receptor 4 ( TLR4 ) Asp-299-->Gly polymorphism has been shown to reduce lipopolysaccharide responsiveness. We examined whether this TLR4 polymorphism is associated with severity of SIRS. A trend was found between the minor...
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