Article
Human toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy.
The Pediatric infectious disease journal - 1 Jan 2006
Faber Joerg, Meyer Claudius U, Gemmer Christina, Russo Alexandra, Finn Adam, Murdoch Craig, Zenz Werner, Mannhalter Christine, Zabel Bernhard U, Schmitt Heinz-J, Habermehl Pirmin, Zepp Fred, Knuf Markus
Abstract excerpt
Toll-like receptor 4 (TLR4) is required for efficient recognition of bacterial infections. We investigated an association between 2 TLR4 mutations (Asp(299)Gly and Thr(399)Ile) and meningococcal disease in 197 patients and 214 healthy controls by allele-specific real time polymerase chain reaction and direct sequencing. Although the allele frequency was not higher in the overall patient population, a...
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