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Article

A functional polymorphism of toll-like receptor 4 is not associated with likelihood or severity of meningococcal disease.

The Journal of infectious diseases - 1 Sept 2001

Read R C, Pullin J, Gregory S, Borrow R, Kaczmarski E B, di Giovine F S, Dower S K, Cannings C, Wilson A G

Abstract excerpt

Human Toll-like receptor 4 (TLR4) transduces proinflammatory cytokine release by human cells in response to lipopolysaccharide (LPS). This study tested the hypothesis that, if TLR4 is rate limiting for a successful response to bacterial LPS in humans, a human gene polymorphism that results in the amino acid substitution Asp299Gly and causes reduced expression and function of TLR4 should influence susceptibility...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11494169
DOI: 10.1086/322798

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A functional polymorphism of toll-like receptor 4 is not associated with likelihood or severity of meningococcal disease.PMID 11494169Read ↗

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Effects of functional Toll-like receptor-4 mutations on the immune response to human and experimental sepsis.Semantic proximity Read ↗

Human toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy.Semantic proximity Read ↗

Polymorphisms in Toll-like receptors-2 and -4 are not associated with disease manifestations in acute Q fever.Semantic proximity Read ↗

Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the Toll-like receptor 4 gene show no deficit in lipopolysaccharide signalling.Semantic proximity Read ↗

Common human Toll-like receptor 4 polymorphisms--role in susceptibility to respiratory syncytial virus infection and functional immunological relevance.Semantic proximity Read ↗

Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility.Semantic proximity Read ↗

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